Where can I find antibody sequences?
OVERVIEW OF DATABASE CONTENT
| Database | Link | Data use |
|---|---|---|
| RAN | recombinant-antibodies.org | Source for Recombinant Antibody Network antibodies |
| RCSB/PDB | X-ref for 3D structures Source for published sequences | |
| UniProt | X-ref for protein targets | |
| WIPO Patents | patentscope.wipo.int | X-ref for patent publications |
What is a CDR sequence?
Complementarity-determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules bind to their specific antigen. A set of CDRs constitutes a paratope.
What is IgBLAST?
IgBLAST is a robust tool for IG sequence analysis. A query sequence can be a full length or a partial IG V domain sequence and does not need to contain a D or J gene (although a V gene sequence containing at least nine bases of a germline V gene is required).
What is antibody sequencing?
Antibody protein sequencing is simply defining the sequence of amino acids of an unknown antibody. The use of mass spectrometry in de novo sequencing of antibody protein has made it possible to perform this without having the cell lines available or knowing the DNA sequence beforehand.
What is the constant region of an antibody?
This region of the antibody is called the Fab (fragment, antigen binding) region. It is composed of one constant and one variable domain from each heavy and light chain of the antibody. The paratope is shaped at the amino terminal end of the antibody monomer by the variable domains from the heavy and light chains.
What are chimeric antibodies?
Chimeric antibodies are structural chimeras made by fusing variable regions from one species like a mouse, with the constant regions from another species such as a human being.
What is Mole blast?
MOLE-BLAST is an experimental tool that helps taxonomists find closest database neighbors of submitted query sequences. It computes a multiple sequence alignment (MSA) between the query sequences along with their top BLAST database hits, and generates a phylogenetic tree.
Why do medicines end in Mab?
They work in different ways to kill the cancer cell or stop it from growing. They all have names that include ‘mab’ at the end of their generic name. For example, trastuzumab (Herceptin) and rituximab (Mabthera). Some MABS help the immune system to attack and kill cancer cells.
