What kind of drug is dacarbazine?
Dacarbazine belongs to the group of medicines called alkylating agents. It is used to treat cancer of the lymph system and malignant melanoma (a type of skin cancer). It may also be used to treat other kinds of cancer, as determined by your doctor.
What does dacarbazine do for cancer?
Dacarbazine belongs to a group of chemotherapy drugs called alkylating agents. It works by sticking to the cancer cell’s DNA and damaging it. The DNA is the genetic code that controls everything the cell does. If the DNA is damaged, the cancer cell cannot divide into 2 new cells.
How is dacarbazine administered?
Dacarbazine can be administered as single agent in doses of 200 to 250 mg/m2 body surface area/day as an i.v. injection for 5 days every 3 weeks. As an alternative to an intravenous bolus injection dacarbazine can be administered as a short-term infusion (over 15 – 30 minutes).
What is another name for dacarbazine?
DTIC-Dome is the trade name for dacarbazine. DTIC and DIC or imidazole carboxamide are other names for dacarbazine. In some cases, health care professionals may use the trade name DTIC-Dome or other names DTIC or DIC or imidazole carboxamide when referring to the generic drug name dacarbazine.
What are the side effects of dacarbazine?
Dacarbazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea.
- vomiting.
- loss of appetite.
- diarrhea.
- sores in the mouth and throat.
- hair loss.
- feeling of burning or tingling on the face.
- flushing.
What is vedotin?
Brentuximab vedotin contains a monoclonal antibody that binds to a protein called CD30, which is found on some lymphoma cells. It also contains an anticancer drug, which may help kill cancer cells. Brentuximab vedotin is a type of antibody-drug conjugate. Also called Adcetris and SGN-35.
What type of chemo is temozolomide?
Temozolomide is a type of chemotherapy. It is also known as Temodal. You might have it as a treatment for a type of brain tumour called malignant (cancerous) glioma. Malignant glioma includes glioblastoma multiforme (GBM) and anaplastic astrocytoma.
What base positions are modified by dacarbazine?
Dacarbazine works by methylating guanine at the O-6 and N-7 positions. Guanine is one of the four nucleotides that makes up DNA.
Which is the most serious side effect of doxorubicin?
Get medical help right away if you have any very serious side effects, including: chest pain. Within days to weeks after doxorubicin treatment, a serious skin reaction that looks likes a severe sunburn (radiation recall) may develop on any area of skin that has been previously treated with radiation.
When do doxorubicin side effects start?
Nausea or vomiting (You will be pretreated for this side effect)Later Side Effects: (within two weeks after treatment begins)
