What is vial crimping?
The process of crimping an aluminum seal onto a pre-stoppered vial should not be overlooked or underemphasized. If a jaw-type crimper must be used, the recommendation is to have a unique jaw-head change part for each combination of vial, stopper and seal.
What are headspace vials?
Headspace vials are a kind of laboratory vials for top space analysis, with the features of high-temperature resistance and corrosion resistance. In this process, since the liquid samples are at the bottom, the material in the top gas can be measured without touching the liquid in the sample vial.
WHAT IS A crimp top vial?
Crimp top vials, which require an 11mm seal, are available in a variety of styles. These vials have a solid glass finish and are available with a 4.6 or 6.0mm ID opening. The crimp seals for these vials are available in a variety of colors.
How do you close vials?
Closed-vial process summary The vial is delivered to the pharmaceutical filling site for filling. In this process, a needle punctures the stopper and dispenses the liquid. The puncture trace is then resealed with a laser to restore the closure integrity. Finally, the vial is capped with a snap-fit, polyethylene cap.
What is headspace GC used for?
Headspace GC is a sample preparation method for determining volatile compounds in solid and liquid samples. The technique has existed since the late 1950s [12] and is still actively used. With this technique, only the gas phase above the sample is introduced into the GC column.
How does headspace GC work?
The method uses headspace gas injected into a gas chromatographic column (GC) to determine the original concentration in a water sample. A sample of water is collected in the field in a vial without headspace and capped with a Teflon septum or crimp top to minimize the escape of volatile gases.
How are vials sealed?
Vial Sealing Process The vials or bottles are manually placed on the machine by the operator. Once placed, the sealing process is initiated, and the sealing head moves down to compress the vial stopper until the closed-loop compression force feedback confirms the operator programmed compression setting is achieved.
How does headspace extraction work?
Headspace sampling is essentially a separation technique in which volatile material may be extracted from a heavier sample matrix and injected into a gas chromatograph for analysis.
Do you recommend screw cap headspace vial or crimp cap head space vial?
We don’t just recommend screw cap headspace vial or crimp cap headspace vial by “feel” or price, running a little experiment to compare the performance of the two kind of headspace vial caps. The experiment was designed to analyze a few very volatile sample and gather data to prevent which type cap of headspace vial is better.
Can You crimp the same Cap twice on the same vial?
The electronic crimpers do rely on the opposing force of the crimping to come to a complete stop, however, so repeatedly crimping the same cap on a vial should not be attempted. (It can also lead to interference between the jaws and the vial sides in some cases).
What are headspace vials made of?
Headspace vials are made of superior quality 1st hydrolytic class glass (Type 1) and have a thicker glass wall to withstand higher temperature and internal pressure for the analysis of volatile gas in the vial’s headspace.
How do I get a good crimp allowance for my vials?
That isn’t to say that there is a quality issue – to get a good crimp allowance has to be made for normal variation in the vials and seals. So – adjust the crimper between lots, and adjust the crimper when the appearance of the cap or seal after crimping changes noticeably.
