What is the most common cause of macrocytic anemia?
The most common causes of megaloblastic, macrocytic anemia are deficiency or defective utilization of vitamin B12 or folate.
What conditions are associated with macrocytic anemia?
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- Vitamin B-12 deficiency.
- Folate deficiency.
- Liver disease.
- Alcoholism.
- Hypothyroidism.
- A side effect of certain medications, such as those used to treat cancer, seizures and autoimmune disorders.
- Increased red blood cell production by the bone marrow to correct anemia, for example, after blood loss.
What is the treatment for macrocytic anemia?
Management of macrocytosis consists of finding and treating the underlying cause. In the case of vitamin B-12 or folate deficiency, treatment may include diet modification and dietary supplements or injections. If the underlying cause is resulting in severe anemia, you might need a blood transfusion.
What causes Macrocytic Hypochromic anemia?
resulting from vitamin C deficiency; hypochromic macrocytic anemia, caused by folate deficiency, vitamin B12 deficiency, or certain chemotherapeutic agents; and pernicious anemia, resulting from vitamin B12 deficiency.
Should I be worried if my MCV is high?
If the MCV goes up to an extreme of 125, it may indicate vitamin B12, folate deficiencies, or cold agglutinin disease. A higher MCV value indicates that the red blood cells are larger than the average size.
Is MCV 103 high?
An average MCV score is between 80 and 95. If the MCV goes up to an extreme of 125, it may indicate vitamin B12, folate deficiencies, or cold agglutinin disease. A higher MCV value indicates that the red blood cells are larger than the average size.
What medications cause high MCV?
Common drugs that cause macrocytosis are hydroxyurea, methotrexate, zidovudine, azathioprine, antiretroviral agents, valproic acid, and phenytoin (Table 1).
