What is Southeast Asian ovalocytosis?

What is Southeast Asian ovalocytosis?

Disease definition. Southeast Asian ovalocytosis (SAO) is a rare hereditary red cell membrane defect characterized by the presence of oval-shaped erythrocytes and with most patients being asymptomatic or occasionally manifesting with mild symptoms such as pallor, jaundice, anemia and gallstones.

Why is there a high incidence of people with Sao in Southeast Asia?

1997; Serjeantson et al. 1997). The high prevalence of SAO is due to the result of natural selection by malaria infection, since SAO provides defense against malaria.

What is Ovalocytosis?

Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the person’s red blood cells are elliptical rather than the typical biconcave disc shape. Such morphologically distinctive erythrocytes are sometimes referred to as elliptocytes or ovalocytes.

How is Ovalocytosis treated?

Topic Outline

1. Overview of clinical features.
2. Abnormal RBC morphologies.
3. Hemolysis, splenomegaly, gallstones.
4. Findings in specific syndromes. Common HE. Hereditary pyropoikilocytosis (HPP) Southeast Asian ovalocytosis (SAO) Hereditary spherocytic elliptocytosis (HSE)

What causes teardrop cells?

Teardrop cells (dacrocytes) are frequently associated with infiltration of the bone marrow by fibrosis, granulomatous inflammation, or hematopoietic or metastatic neoplasms. They can also be seen in patients with splenic abnormalities, vitamin B12 deficiency, and some other forms of anemia.

Are ovalocytes bad?

Ovalocytes are egg-shaped RBCs commonly associated with vitamin B12 or folate deficiencies or megaloblastic anemias. The more severe the deficiency, the more prevalent the ovalocytes. Ovalocytes are frequently destroyed in the spleen, causing anemia.

What is Melanesian Ovalocytosis?

Southeast Asian ovalocytosis is a blood disorder that is similar to, but distinct from hereditary elliptocytosis. It is common in some communities in Malaysia and Papua New Guinea, as it confers some resistance to cerebral Falciparum Malaria.

What are the symptoms of Poikilocytosis?

Symptoms of poikilocytosis

• fatigue.
• pale skin.
• weakness.
• shortness of breath.

Is Ovalocytes hereditary?

Hereditary ovalocytosis is a rare condition passed down through families (inherited). The blood cells are oval-shaped instead of round. It is a form of hereditary elliptocytosis.