What is mucinosis skin?
Mucinoses are a diverse group of uncommon skin disorders. All involve accumulation in the skin of abnormal amounts of mucin. This is a jelly-like complex carbohydrate substance, called hyaluronic acid, that occurs normally as part of the connective tissue in the dermis or mid-layer of the skin.
What is follicular Mucinosis?
Follicular mucinosis is a rare cutaneous mucinosis characterized by accumulation of mucin at the external root sheath and sebaceous glands [1]. It manifests clinically as follicular papules distributed on the trunk, proximal limbs, scalp, and face; it may also exist as indurated plaques [2].
What causes alopecia Mucinosa?
Alopecia mucinosa is a disease process defined histopathologically by mucin deposition in hair follicles and sebaceous glands, which undergo epithelial reticular degeneration. The exact pathogenesis is unknown, although the role of circulating immune complexes and cell-mediated immunity has been considered.
What does follicular Mucinosis look like?
Typically there are pink papules (small bumps) or plaques (larger raised or thickened areas of skin) with prominent pores which are the hair follicle openings. The mucin (gelatinous clear material) may ooze from these pores, especially if the area is touched or squeezed.
Is Focal mucinosis benign?
Cutaneous focal mucinosis (CFM) is a benign form of primary cutaneous mucinosis that is specifically described as a de-generative inflammatory mucinosis. It is a rare condition characterized by asymptomatic singular dermal mucin deposition and histopathologic homogenous mucin deposition in the dermis.
What is oral focal mucinosis?
Acral persistent papular mucinosis (APPM) is a rare subtype of localized lichen myxedematosus. It consists of small papules localized exclusively on the back of the hands, wrists and extensor aspects of distal forearms with no other clinical or laboratory manifestations.
What is focal Mucinosis?
Cutaneous focal mucinosis (CFM) is a localized form of cutaneous dermal mucinosis clinically presenting as an asymptomatic skin-colored papule or nodule that occurs anywhere on the body or in the oral cavity. The etiopathogenesis of CFM is unclear, but it is thought to represent a reactive and not a neoplastic lesion.
What is reticular erythematous Mucinosis?
Reticular erythematous mucinosis (REM) is a rare form of primary cutaneous mucinosis, most often involving the midline of the upper chest or back in middle-aged women. REM bears clinical and histopathologic resemblance to lupus erythematosus tumidus (LET), dermatomyositis, scleredema, and lichen myxedematosus.
Is follicular Mucinosis curable?
Follicular mucinosis is suggested to be a localized form of cutaneous T-cell lymphoma. There exists no treatment of choice for follicular mucinosis.
Is follicular Mucinosis itchy?
Urticaria–like follicular mucinosis Presents as itchy small bumps (papules) or raised areas (plaques). These are mostly found on the head and neck.
How common is follicular Mucinosis?
Follicular mucinosis is a rare disorder. The primary form occurs in children and young adults. In the absence of other disorders, it commonly shows localized lesions of the face, head and neck that have a tendency to resolve within two months to two years.
What is follicular mucinosis and how is it treated?
Follicular mucinosis also known as alopecia mucinosa, is a rare skin disorder characterized by follicular degeneration due to the accumulation of mucin within the pilosebaceous unit (hair follicle), with associated inflammatory changes 1). Follicular mucinosis describes the appearance of mucin around hair follicles as seen under the microscope.
How is Urticaria-like follicular mucinosis (rare) differentiated from mycosis fungoides?
Urticaria-like follicular mucinosis (rare). There is no known way to differentiate idiopathic follicular mucinosis from mycosis fungoides or cutaneous T-cell lymphoma-associated follicular mucinosis with certainty.
Is follicular mucinosis a form of cutaneous T-cell lymphoma?
Some investigators propose that follicular mucinosis is in fact a form of mycosis fungoides or cutaneous T-cell lymphoma, with a relatively benign or unpredictable course, while others propose that it may be a cutaneous T-cell lymphoid dyscrasia.
What are the signs and symptoms of follicular papules (folliculitis)?
Patients most commonly present with follicular papules and indurated plaques and hair loss.[1] It is a disease process characterized by mucin deposition within the follicular epithelium with a superficial and deep perivascular and interstitial mixed-cell infiltrate. Previous reports have shown variation in the amount of follicular mucin.
