What does cholesteryl ester transfer protein do?
Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins.
What is cholesteryl ester transfer protein inhibitors?
Cholesteryl ester transfer protein (CETP) inhibitors, including dalcetrapib, evacetrapib, and anacetrapib, are novel agents that have been developed to increase serum high-density lipoprotein cholesterol (HDL-c) concentration.
What is the difference between cholesterol and cholesteryl esters?
Cholesterol is an important sterol component in animals. The key difference between cholesterol and cholesteryl esters is the active and the inactive forms. Cholesterol is an active sterol form whereas cholesteryl ester is an inactive esterified form in which cholesterol is transported in the circulatory system.
What do CETP inhibitors do?
CETP inhibitors inhibit cholesterylester transfer protein (CETP), which normally transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins (VLDL or LDL). Inhibition of this process results in higher HDL levels and reduces LDL levels.
Is CETP good or bad?
Since CETP activity can reduce HDL-cholesterol concentrations and CETP deficiency is associated with elevated HDL-cholesterol levels, CETP inhibitors have become a highly sought-after pharmacological target for the treatment of heart disease.
Why is cholesterol converted to cholesteryl esters?
To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. This vastly increases the capacity of lipoproteins, allowing for more efficient cholesterol transport through the blood stream.
What is cholesteryl ester storage disease?
Cholesteryl ester storage disease (CESD) is a type of lysosomal acid lipase (LAL) deficiency; a rare genetic disorder characterized by a deficiency of the lysosomal acid lipase (LIPA or LAL) enzyme. This enzyme is essential for hydrolysis of triglycerides and cholesteryl esters in lysosomes.
What is CETP deficiency?
CETP deficiency – This asymptomatic, hereditary syndrome is caused by low CETP levels. Decreased CETP activity slows the transport of cholesteryl esters from HDL to apo B–containing lipoproteins. The condition is frequently observed in Japanese Americans.
Which protein is deficient in Tangier disease?
Tangier disease results in familial high-density lipoprotein deficiency. High-density lipoproteins are created when a protein in the bloodstream, Apolipoprotein A1 (apoA1), combines with cholesterol and phospholipids.
What is CETP function?
CETP is a hydrophobic glycoprotein that is secreted mainly from the liver and that circulates in plasma, bound mainly to HDL. It promotes the redistribution of cholesteryl esters, triglycerides, and, to a lesser extent, phospholipids between plasma lipoproteins.
