What do Translocators do?
TSPO (Translocator protein) acts to regulate heart rate and contractile force by its interaction with voltage-dependent calcium channels in cardiac myocytes. The interaction between TSPO and calcium channels can alter cardiac action potential durations, thus contractility of the heart.
What is translocation in cell biology?
Translocation is a type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosome. Chromosomal translocations can be detected by analyzing karyotypes of the affected cells.
What are translocations in genetics?
Listen to pronunciation. (TRANZ-loh-KAY-shun) A type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosomal location.
Where is the protein Translocator located?
outer mitochondria membrane
Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain.
What is protein translocation?
Protein translocation is a process by which proteins move between cellular compartments. Short amino-acid sequences within a protein, known as signal peptides or signal sequences, can direct its localisation, although translocation also occurs in the absence of these signal sequences.
What is translocation in biology class 10?
Translocation is the process by which plants deliver minerals, plant growth hormones, water, and organic substance over long distances throughout the plants (from leaves to other parts). These food nutrients are translocated in the form of solutes in a solution known as phloem sap.
What is translocation in protein?
Definition. Protein translocation is a process by which proteins move between cellular compartments. Short amino-acid sequences within a protein, known as signal peptides or signal sequences, can direct its localisation, although translocation also occurs in the absence of these signal sequences.
What are the types of translocation in plants?
Exchange of segments between two or more non-homologous chromosomes is called reciprocal translocation or interchange. It is of two types: asymmetrical or aneucentric and symmetrical or eucentric.
Why do chromosomal translocations occur?
Translocations occur when chromosomes become broken during meiosis and the resulting fragment becomes joined to another chromosome. Reciprocal translocations: In a balanced reciprocal translocation (Fig. 2.3), genetic material is exchanged between two chromosomes with no apparent loss.
What is the translocator protein?
Translocator Protein Structure and Function. In mitochondria, it was first recognized as an outer membrane protein that binds benzodiazepine drugs, but distinct from the central nervous system site, the GABA A receptor (1). Originally called the peripheral benzodiazepine receptor (PBR), it was renamed the translocator protein or TSPO,…
What does translocation mean in biology?
Translocation. Translocation. =. Translocation is a type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosome. Chromosomal translocations can be detected by analyzing karyotypes of the affected cells.
How do you detect chromosomal translocations?
Chromosomal translocations can be detected by analyzing karyotypes of the affected cells. A translocation is a chromosomal abnormality whereby there’s a break in the chromosome, one particular chromosome, and that chromosome will then fuse to a different chromosome.
What is the function of mitochondrial translocator protein 18 kDa?
To gain insights into the TSPO function, the Ferguson-Miller lab determined the high-resolution crystal structures of the Rhodobacter homolog of mitochondrial translocator protein 18 kDa (TSPO), as well as a mutant form mimicking a human disease-related polymorphism, using lipidic cubic phase technology.
