Is sodium phenylbutyrate water soluble?
The chemical name for sodium phenylbutyrate is 4-phenylbutyric acid, sodium salt. It forms water-soluble off-white crystals.
What is sodium phenylbutyrate used for?
Sodium phenylbutyrate is used together with a proper diet to help treat urea cycle disorders (including a specific liver enzyme deficiency) that help remove ammonia (nitrogen) from the body.
How is sodium phenylbutyrate metabolized?
Sodium phenylbutyrate is metabolized in the liver and kidneys to phenylacetylglutamine, which is primarily excreted by the kidneys. Pheburane should therefore be used with caution in patients with renal insufficiency (CrCl or eGFR < 60 mL/min).
Is sodium a butyrate?
In the lab, sodium butyrate is usually found as a white, water-soluble, crystalline solid. The chemical is notable for having a very strong, unpleasant smell that lingers….Sodium butyrate.
| Names | |
|---|---|
| Chemical formula | C4H7NaO2 |
| Molar mass | 110.088 g·mol−1 |
How can urea be prevented?
The best ways to prevent urea volatilization are to apply it during cool periods, or incorporate the fertilizer one or two days after application either with tillage or with one-half-inch or more of irrigation or rain.
What is sodium phenylbutyrate (6-pba)?
Sodium phenylbutyrate is a salt of an aromatic fatty acid, 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.
Is sodium benzoate a 4-phenylbutyrate?
It contains a 4-phenylbutyrate. Phenylbutyrate and sodium benzoate are orphan drugs approved for the treatment of hyperammonemia in patients with urea cycle disorders, a series of at least 8 rare genetic enzyme deficiencies.
What is 4-phenylbutyrate anion?
4-phenylbutyrate is a carboxylic acid anion obtained by the removal of proton from the carboxy group of 4-phenylbutyric acid. It is a conjugate base of a 4-phenylbutyric acid. Substances that inhibit or prevent the proliferation of NEOPLASMS.
What citations are available for sodium 4-phenylbutyrate?
Citations are publications that use Tocris products. Selected citations for Sodium 4-Phenylbutyrate include: Myszor et al (2019) Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity.
