Is indapamide the same as hydrochlorothiazide?

Is indapamide the same as hydrochlorothiazide?

Indapamide, a non-thiazide diuretic, lowers systolic blood pressure 54% more than HCTZ. In addition to being more potent that HCTZ, indapamide has a number of other benefits.

Is indapamide an ACE inhibitor?

Indapamide is a thiazide-like diuretic drug generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available….Indapamide.

Is indapamide a vasodilator?

Since indapamide is a thiazide-like agent with antihypertensive properties at doses that provoke minimal diuretic effects,15 its mode of action is thought to be due to a combined diuretic and vasodilator effect.

Where is indapamide metabolised?

Studies of 14C-labeled indapamide in humans demonstrate that 70% of the radioactivity is excreted in urine and 23% in feces. Indapamide is extensively metabolized; less than 7% of the dose is excreted in urine as unchanged compound.

What is the side effect of indapamide?

Check with your doctor right away if you have confusion, decreased urine, dizziness, drowsiness, dry mouth, increased thirst, fast or irregular heartbeat or pulse, headache, muscle pains or cramps, nausea or vomiting, seizures, swelling of the face, ankles, or hands, trouble breathing, or unusual tiredness or weakness.

Can indapamide cause erectile dysfunction?

For High Blood Pressure: “Took Indapamide 2.5mg for 2 years. It helped a little with blood pressure but it caused complete sexual dysfunction.”

Is indapamide a blood thinner?

Indapamide is a type of medicine called a thiazide-like diuretic. Diuretics make your body get rid of extra fluid through your kidneys. This increases the amount of salts (such as sodium and potassium) and water you pee out. This means you have less fluid in your body and blood, which helps reduce blood pressure.

How is indapamide metabolized?

Indapamide is extensively metabolized by cytochromes P450. Interaction of indapamide and other antihypertensive drugs are unknown. We investigated the effects of other antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in vitro and in vivo.