Is chromosomal translocation bad?
Depending on the chromosome breakpoints, a translocation can result in the disruption or misregulation of normal gene function. These molecular rearrangements, in many cases, are considered to be the primary cause of various cancers.
What diseases are caused by chromosomal translocation?
Examples
| Translocation | Associated diseases | Fused genes/proteins |
|---|---|---|
| First | ||
| t(9;22)(q34;q11) Philadelphia chromosome | Chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL) | Abl1 gene on chromosome 9 |
| t(15;17)(q22;q21) | Acute promyelocytic leukemia | PML protein on chromosome 15 |
What is heterozygous translocation?
an individual carrying cells with one normal set of chromosomes and one set in which a reciprocal TRANSLOCATION has occurred between two non-HOMOLOGOUS CHROMOSOMES.
What does mutation translocation mean?
Listen to pronunciation. (TRANZ-loh-KAY-shun) A genetic change in which a piece of one chromosome breaks off and attaches to another chromosome. Sometimes pieces from two different chromosomes will trade places with each other.
What is complex translocation heterozygotes?
Complex heterozygotes are viable heterozygotes for multiple reciprocal translocations A when translocation homozygotes are lethal (see Fig. C144). It is actually a balanced lethal system and heterozygosity is permanent for the genes within the translocation complexes.
What causes translocation mutations?
Translocations. A translocation occurs when a piece of one chromosome breaks off and attaches to another chromosome. This type of rearrangement is described as balanced if no genetic material is gained or lost in the cell. If there is a gain or loss of genetic material, the translocation is described as unbalanced .
Does balanced translocation cause birth defects?
This is because a person with a balanced translocation can make egg or sperm cells with too much of one chromosome and too little of the other. This can cause infertility, miscarriage or the birth of a child with intellectual disabilities and/or birth defects.
