How is Depakote dosed?
Depakote tablets are administered orally. The recommended initial dose is 750 mg daily in divided doses. The dose should be increased as rapidly as possible to achieve the lowest therapeutic dose which produces the desired clinical effect or the desired range of plasma concentrations.
Should Depakote be taken in the morning or at night?
A: You should take Depakote at a time of day when you can best remember to take it consistently—for instance, in the morning with breakfast or in the evening before you go to bed. Please see Full Prescribing Information with Medication Guide for the complete list of side effects.
How many hours apart should you take Depakote?
Since Depakote ER is generally taken once every 24 hours, they should allow an interval of about 12 hours before taking the second dose, and then resume a 24-hour schedule the next day. Patients who often forget doses may benefit from using a special pillbox or watch with an alarm.
How many mg of Depakote does it take to overdose?
400 — 1000 mg/kg: severe toxicity, i.e. Coma.
How much Depakote should I take for bipolar?
Dosage formulations for acute bipolar mania
| DEPAKOTE Delayed-Release Tablets | DEPAKOTE ER Tablets | |
|---|---|---|
| MAXIMUM RECOMMENDED DOSE | 60 mg/kg/day | |
| THERAPEUTIC BLOOD RANGE | Clinical response was dosed at trough plasma concentrations between 50-125 μg/mL | 85 to 125 μg/mL |
What is a high level of Depakote?
Reference Range Depakote The reference ranges for valproic acid are as follows: The therapeutic range for valproic acid (total) is 50-125 µg/mL. The toxic level is greater than 150 µg/mL. The therapeutic range for valproic acid (free) is 6-22 µg/mL.
Does Depakote affect sleep?
Has anyone had sleeping problems on Depakote? Epilepsy Foundation.
Can I take 1500 mg of Depakote?
Maintenance dosage in usually in the range of 1000-1500 mg. daily, sometimes higher. The target blood level is 50-100 micrograms/milliliter of blood, though some people’s symptoms are best controlled at slightly lower or higher levels.
Is 2500 mg of Depakote too much?
Depakote tablets are administered orally. The recommended starting dose is 250 mg twice daily. Some patients may benefit from doses up to 1,000 mg/day. In the clinical trials, there was no evidence that higher doses led to greater efficacy.
