How do I remember the drug interactions with warfarin?

How do I remember the drug interactions with warfarin?

Interaction Mnemonics

1. O-DEVICES – is a mnemonic you can use to remember drugs that inhibit the cytocrhome p450 enzyme system and thus increase the effects of warfarin:
2. O – Omperazole.
3. D – Disulfiram.
4. E – Erythromycin.
5. V – Valproate.
6. I – Isoniazid.
7. C – Cimetidine + Ciprofloxacin.
8. E – Ethanol (Acutely)

What drugs does warfarin interact with?

Common drugs that can interact with warfarin include:

• Aspirin or aspirin-containing products.
• Acetaminophen (Tylenol, others) or acetaminophen-containing products.
• Antacids or laxatives.
• Many antibiotics.
• Antifungal medications, such as fluconazole (Diflucan)
• Cold or allergy medicines.

What are the Fab 5 with warfarin?

Four significant drug interactions with warfarin are: fluconazole, amiodarone, sulfamethoxazole/trimethoprim, and metronidazole. Potentially life-threatening interactions with these medications are a common occurrence because they have a broad spectrum of indications in elderly individuals.

How do you adjust warfarin based on INR?

A nice “rule of thumb” for dose adjustments near the target range (generally works for INRs from the high 1s to low 4s): If you want to change the INR by 0.5-1 unit, increase or decrease the weekly dose by a daily dose. Example: Your patient has been taking warfarin 5mg daily for more than 2 weeks and INR is 1.8.

What is contraindicated with warfarin?

Contraindicated in: Recent brain, eye, or spinal cord injury or surgery; Severe liver or kidney disease; Uncontrolled hypertension; OB: Crosses placenta and may cause fatal hemorrhage in the fetus.

What medications should be avoided when taking warfarin?

What medicines should I avoid while taking warfarin?

• aspirin.
• acetaminophen (Tylenol)
• ibuprofen (Advil, Motrin)
• diclofenac (Cataflam, Voltaren)
• indomethacin (Indocin)
• naproxen (Aleve, Naprosyn)
• piroxicam (Feldene)
• celecoxib (Celebrex)

How can I remember the colors of warfarin?

Helpful Mnemonics

1. mg. Leaves. Lavender.
2. mg. Granny. Green. 2.5 mg. Bleeding. Brown.
3. mg. Bloody. Blue.
4. mg. Profusely. Peaches.
5. mg. Thank. Teal.
6. mg.

Does amiodarone inhibit warfarin?

Amiodarone is a potent inhibitor of the enzymes responsible for warfarin metabolism. Decreased metabolism of warfarin leads to higher plasma concentrations and an increased risk of bleeding complications.

How do you manage high INR?

Asymptomatic patients with an INR that is only slightly above the therapeutic maximum can often be managed simply by omitting their usual warfarin dose and increasing their frequency of INR monitoring. The INR will reduce over several days. Warfarin should be restarted, if necessary, when the INR falls below 5.0.